The three children, aged 13, were arrested by Israeli police who were accompanied by intelligence agents, Follow-Up Committee member Muhammad Abul Humus told Ma’an.
A spokesman for Israel’s police was not immediately available for comment.
The detentions follow a raid on Wednesday in the area during a wedding party, where one Palestinian was injured by Israeli fire. Three detentions were also made during the raid.
Issawiya is the hometown of Samer Issawi, who ended a 266-day hunger strike on Wednesday after Israel agreed to release him in eight months.
Israeli forces have repeatedly raided the neighborhood amid frequent protests over Issawi’s detention, dismantling a solidarity tent in the town over 30 times.